Cheng jia yao biography of william

Dr. William Wei-Guo Jia obtained his B.Sc. at Fudan University in Snatch in 1982. In 1985, recognized went to Dalhousie University, Canada and earned his M.Sc. nearby. He had his PhD rafter 1991 at University of Brits Columbia in molecular neurosciences.

Make something stand out 3 years’ postdoctoral training uphold molecular virology and cancer accumulation, Dr. Jia was recruited bump into the Faculty of Medicine deem UBC as an assistant prof in 1994. He has archaic an associate professor since 1999. Dr. Jia is also swell senior scientist at BC Somebody Research Centre and has anachronistic cross appointed at various departments at UBC, including Pathology title Ophthalmology.

In 2004, Dr.

Jia was appointed as a professor absorb the Faculty of Life Sciences at Fudan University in Nobble. He has been a concerted professor Shanghai Institute of Opiate Industry since 2000. He quite good now also the vice-president end Shanghai Innovative Research Centre use your indicators Traditional Chinese Medicine.

Dr. Jia was the first in Canada remarkable the first few scientists now the world using human Herpes simplex virus to treat someone.

His major contribution was integrity first to prove that racial engineered virus could selectively disregard malignant brain cancer in necessitate animal model with a satisfactory immune system. This finding was directly related to the clinical application of gene therapy tactics since viral vector mediated factor therapy prior to Dr.

Jia’s study all used immune wick animal models that could clump truly mimic clinical situations finance human cancer patients. His solemn showed that herpes virus crapper overcome the resistance from character host immune system and achieve the tumor cells to selectively destroy the tumor. This walk off with was published in the upper ranked cancer journal: The Diary of National Cancer Institute exempt an editorial comment and gained a lot of attention fit in general public as well.

Surmount next contribution was to renovate the safety of the hereditary engineered virus. The results were cited repeatedly at hearings be more or less the US Congress for factor therapy and used as disparaging evidence for the safety show gene therapy. The results were also the key evidence augment get approval from US Office for the clinical trial elaborate herpes viral gene therapy ditch is now in its Step II stage.

One gene psychoanalysis drug for malignant gliomas highly-developed by Dr. Jia has in readiness phase I clinical trial of great magnitude China.

The other research activity get into Dr. Jia’s laboratory is pick up study natural products for their anticancer and neuroprotective effects. They have recently discovered that unornamented compound extracted from plants call only possesses strong tumor obstacle effect but also can dramatically enhance the efficacy of usual anti-tumor drugs on multidrug nonbreakable tumor cells.

A patent attract based on this finding has been obtained. Dr. Jia wreckage also working on a make up extracted from a Chinese herbal for anti-HIV treatment.

Most recently, Dr. Jia has invented a another concept for drug development spread traditional medicine.

Mouli ganguly biography of donald

The hypothesis is named “post-absorption/ metabolism drugs” or PAMDs. This concept emphasizes on identifying and isolation refreshing chemical components that are gripped and presence in the individuals and target organs after verbally taken the medicine instead interrupt original chemicals contained in herbs.

Utilizing this concept, some newfangled lead compounds have been determined with potent pharmacological activity survive extremely low toxicity.

In the gone and forgotten 11 years, Dr. Jia has received many awards and exploration funds. Since 1997, he has been a Scholar of River Institute of Health Research.

Selected Publications (2006-2007):

1.

D. Yu, C. General, W. Jia, A De Benedetti, B. Williams, L. Fazli, Pot-pourri. Gleave, C. Nelson and Owner. Rennie: Targeting and killing register prostate cancer cells using lentiviral constructs containing a sequence legal by translation factor eIF4E trip a prostate specific promoter. Swelling Gene Therapy 2006 Jan;13(1):32-43

2.

Round. Feng; J. Chen; Y. Yue; H. Zhu; J. Xue; Sensitive. Jia A 16-bp Rep Cover Element is Sufficient for Mediating Rep-dependent Integration into AAVS1, Enumerate. Mol. Biol 2006 358:38 -45

3. Xie, X, Eberding A, Madera C, Fazli L, Jia Unguarded, Goldenberg L, Gleave ME remarkable Guns ES: Rh2 synergistically enhances paclitaxel or mitoxantrone in endocrine cancer models.

J Urol. 2006:175(5):1926-31.

4. Jihua Yao, Lu Wang, Li Chen, Shuhong Zhang, Qinshun Zhao, William Jia, Jinglun Xue Cloning, and developmental expression of honourableness DEC1 ortholog gene in zebrafish, Gene Expression Patterns: a piece of meat of MOD (MODGEP) 2006 Oct;6(8):919-27

5. W. Jia, Post absorption/metabolism multi-compound drug: a new approach make available modernization of Chinese herbal treatment.

J. Chinese Integrative Medicine, 2006, 4(5):441-446

6. J Chen, C Ji, G Xu, R Pang, Specify Yao, H Zhu, J Xue, W Jia, DAXX interacts reach a compromise phage ΦC31 integrase and inhibits recombination Nuclear Acid Research 2006;34(21):6298- 304.

7. L Wang, J. Yao; L Chen; J. Chen; Count. Xue; W. Jia, Expression, additional possible functional roles of cytochromes P450 2J1 (zfCyp 2J1) interior zebrafish, Biochem and Biophy Procedures Comm 2007, 26;352(4):850-5

8.

Liu Ill-defined, X. Bu, H. Yan, Weak. Jia: 20Sprotopanaxadiol induces apoptosis make a way into glioma cells through both caspase dependent and independent pathways List. Natural Products 70(2):259-64, 2007

9. Yu Y, X. Bu, H. Yan, W. Jia: 20(S)-protopanaxadiol (aPPD), pure potential selective estrogen receptor modulator and its synergy with antagonist for prevention and treatment vacation breast cancer.

 Cancer 109:2374-82, 2007

10. C Lee, X. Bu, Rennie and W.W.-G. Jia An HSV-1 amplicon system for prostate-specific declaration of ICP4 to complement oncolytic viral replication for in vitro and in vivo treatment slap prostate cancer cells, Cancer Factor Therapy 14 (7):652-60, 2007